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Obesity is a chronic, relapsing disease, characterized by excessive development of the fatty tissue. Obesity occurs more often after 40 years, mostly among the women.

The main factor leading to the obesity, is a violation of the energy balance, which consists in the disparity between energy intakes into the organism and their costs. Most often obesity is caused by overeating, but may occur due to the violations of the control of energy expenditure.
Unquestionable is the role of the hereditary-constitutional predisposition, decreased physical activity, age, sex, occupational factors, some of the physiological conditions (pregnancy, lactation, menopause).
Obesity is the hypothalamic-pituitary disease, in the pathogenesis of which playing a leading role expressed in varying degrees, hypothalamic disorders, which cause behavioral change, especially eating disorders, and hormonal disorders.

Increased activity of the hypothalamic-pituitary-adrenal system: increased secretion of ACTH, cortisol production rate, accelerating its metabolism. Reduced secretion of somatotropic hormone, which has lipolytic activity, disturbed secretion of the gonadotropins and the sex steroids.
Characterized by hyperinsulinemia, reducing its efficiency. Disturbed metabolism of the thyroid hormones and the peripheral tissue sensitivity to them.

We distinguish an alimentary-constitutional, endocrine, and hypothalamic obesity.

Alimentary-constitutional obesity runs in families and develops, usually in a systematic overeating, abuse of diet, lack of adequate physical activity, often with family members or close relatives.

Hypothalamic obesity is caused by the disturbances of hypothalamic functions and therefore has a number of clinical features.

Endocrine obesity is a symptom of primary pathology of the endocrine glands: hypercorticism, hypothyreoism, hypogonadism.

However, in all forms of obesity the hypothalamic disorders are available in the varying degrees, occurring either primary, or in the development of obesity. The common feature of all forms of obesity is excessive body weight.

There are four degrees of obesity and two stages of the disease - progressive and the stable.

• At I degree actual body weight exceeds the ideal by no more than 29%,
• at II degree - we have 30-40% excess,
• at the III degree - we have 50-99% excess,
• for IV degree - actual body weight exceeds the ideal for 100% or more.

Sometimes, the degree of obesity is estimated by the body mass index, calculated as follows: Body weight (kg) / height (m) (squared) is accepted as the norm-mass index, constituting 20-24,9; when I degree - the index is 25 - 29 9, at II degree - 30 - 40, at III degree – index is more than 40.
The patients with I - II degree of obesity usually have no complaints, with more massive degree of obesity they will be worried by weakness, sleepiness, depressed mood, and sometimes nervousness, irritability, nausea, bitter taste in the mouth, shortness of breath, swelling of the lower extremities, pain in joints, spine.

With hypothalamic obesity patients often will be worried by increased appetite, especially in the afternoon, at night feeling hungry, thirsty. For women there will be various menstrual disorders, infertility, hirsutism, for men - lower potency. Patients will have uncleanness and trophic disorders of the skin, small pink stretch marks on thighs, abdomen, shoulders, armpits, neck hyperpigmentation, elbows, places of friction, increased blood pressure.

In the EEG study of patients with hypothalamic obesity the signs of the destruction of the diencephalic brain structures were revealed. Determination of the urinary 17-ACS and 17-COP reveals their modest increase.

For the differential diagnosis of hypothalamic obesity and hypercorticism, small dexametazone test should be made, and also x-ray of skull and spine.

If there is a thirst, dry mouth, determine your blood sugar on an empty stomach and within a day, according to the indications, carry out glucose tolerance test.

With the disorders of the menstrual cycle - gynecological examination, ultrasound of the pelvic organs, measurement of the rectal temperature, other tests of the functional diagnostics should be done.

Treatment and statistics

In the center of Academician Avakyan G.S. the results of the complex therapy of 306 obese patients has been studied. Among them, 87 were men, 219 were women, at the ages of 25 to 59 years. Duration of disease ranged from 3 to 18 years. The patients were examined for the terms of 3 months to 2 years, after start of the treatment.
The main complaints, when you contact the Neurological Center, were:

• increased appetite - 84% of cases;
• general weakness - 89% of cases;
• thirst and concomitant type 2 diabetes -19% of cases;
• disorder for the menstrual function in women - 31% of cases;
• depressed mood - 23% of cases;
• irritability - 30% of cases.

Depending on the duration of the disease, motor mode of the patient, somatoneurological diagnosis, the patient's professional affiliation, a combination of the pharmacological and herbal teas, and their doses were changed. A full course of treatment was 2 years.

Evaluation of the results was carried out independently by patients with help of specific questionnaires and the results of the psychoneurological status, strictly accounting for body weight (the kg), biochemical analysis of blood and urine tests, before and after treatment. The evaluation was conducted in the dynamics (3, 6, 12 and 24 months).
After processing the statistical data the maximum therapeutic effect was observed after 4 weeks of starting treatment.

• permanent loss in weight without a special diet was 3800-4200 g / week in the 100% of cases; • greatly improved the general condition (swelling disappeared, lethargy, fatigue, improved mood) - in 82% of the cases;
• in 61% of cases, the phenomenon of neurologic complications disappeared, with concomitant diabetes (among patients with diabetes).

Contraindications to receive herbal teas: idiosyncrasy of medicinal herbs.

The Mechanism of action

The main properties of these biologically active substances are bionormalizers:

1) The regulation of all types of metabolism (fat, carbohydrate, protein, water and salt);

2) anorexigenic effect (suppression of the appetite), increased lipolysis;

3) antioxidant effect due to the blockade of free radicals at the cellular level, the normalization of cerebral metabolism, reducing the risk of oxygen starvation of the brain. The result - improved cognitive function, improved memory, concentration, increased resistance to physical and psycho-emotional stresses after the 1st course.